Cpsf6
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CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:, PubMed:, PubMed:).
Cpsf6. Entrez Gene Summary for CPSF6 Gene The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. CPSF6 cleavage and polyadenylation specific factor 6 (human) HIV-1 is more dependent on the K1 capsid residue than HIV-2 for interactions with CPSF6. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors.
CPSF6 is a component of the CFIm complex, involved in mRNA 3′end processing. This article on a gene on human chromosome 12 is a stub. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood.
These mutations are displayed at the amino acid level across the full length of the gene by default. Human CPSF6 genome location and CPSF6 gene details page in the UCSC Genome Browser. Plays a role in mRNA export (PubMed:).
This page was last edited on 13 October , at 01. You can help Wikipedia by expanding it.
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